Publications
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- Paper publication
- Unique binding mode of Evogliptin with human dipeptidyl peptidase IV. Biochem Biophys Res Commun. 2017 Dec 16;494(3-4):452-459. doi: 10.1016/j.bbrc.2017.10.101. Epub 2017 Oct 20. PMID: 29061303. Lee HK, Kim MK, Kim HD, Kim HJ, Kim JW, Lee JO, Kim CW, Kim EE.
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- Paper publication
- In vitro evaluation of potential transporter-mediated drug interactions of evogliptin. Biopharm Drug Dispos. 2017 Sep;38(6):398-403. doi: 10.1002/bdd.2083. Epub 2017 Jul 13. PMID: 28503751.Lee DY, Chae HW, Shim HJ.
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- Paper publication
- Bioanalytical validation for the determination of evogliptin and its
metabolites m7/m8 in human plasma by liquid chromatography-tandem mass
spectrometry. Drug Metab Pharmacokinet. vol. 32,1 (2017): S27. doi.org/10.1016/j.dmpk.2016.10.127 Kyunghee Cho, Sun Koung Joung, Sookie La, Dae Young Lee, Hyun Joo Shim, Ji Su Song, Hee Joo Lee
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- Paper publication
- Hepatic role in an early glucose-lowering effect by a novel dipeptidyl peptidase 4 inhibitor, evogliptin, in a rodent model of type 2 diabetes. Eur J Pharmacol. 2016 Jan 15;771:65-76. doi: 10.1016/j.ejphar.2015.11.029. Epub 2015 Nov 24. PMID: 26621343.Kim TH, Kim MK, Cheong YH, Chae YN, Lee Y, Ka SO, Jung IH, Shin CY, Bae EJ, Son MH.
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- Paper publication
- Beneficial Effects of Evogliptin, a Novel Dipeptidyl Peptidase 4 Inhibitor, on Adiposity with Increased Ppargc1a in White Adipose Tissue in Obese Mice. PLoS One. 2015 Dec 3;10(12):e0144064. doi: 10.1371/journal.pone.0144064. PMID: 26633898; PMCID: PMC4669177.Chae YN, Kim TH, Kim MK, Shin CY, Jung IH, Sohn YS, Son MH.
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- Paper publication
- In Vitro Metabolic Pathways of the New Anti-Diabetic Drug Evogliptin in Human Liver Preparations. Molecules. 2015 Dec 4;20(12):21802-15. doi: 10.3390/molecules201219808. PMID: 26690104; PMCID: PMC6332232.Jeong HU, Kim JH, Lee DY, Shim HJ, Lee HS.
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- Paper publication
- DA-1229, a novel and potent DPP4 inhibitor, improves insulin resistance and delays the onset of diabetes. Life Sci. 2012 Jan 2;90(1-2):21-9. doi: 10.1016/j.lfs.2011.10.007. Epub 2011 Oct 20. PMID: 22056373.Kim MK, Chae YN, Kim HD, Yang EK, Cho EJ, Choi SH, Cheong YH, Kim HS, Kim HJ, Jo YW, Son MH, Kim SH, Shin CY.
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- Paper publication
- Discovery of DA-1229: a potent, long acting dipeptidyl peptidase-4 inhibitor for the treatment of type 2 diabetes. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3809-12. doi: 10.1016/j.bmcl.2011.04.029. Epub 2011 Apr 13. PMID: 21570283.Kim HJ, Kwak WY, Min JP, Lee JY, Yoon TH, Kim HD, Shin CY, Kim MK, Choi SH, Kim HS, Yang EK, Cheong YH, Chae YN, Park KJ, Jang JM, Choi SJ, Son MH, Kim SH, Yoo M, Lee BJ.
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- Paper publication
- Pharmacological evaluation and safety of a donepezil patch. Pharmazie. 2020 Dec 1;75(12):656-661. doi: 10.1691/ph.2020.0588. PMID: 33303060.Shin CY, Kim HS, Cha K-, Kim HJ, Choi WS, Jang SW, Sohn UD.
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- Paper publication
- Safety, tolerability, and pharmacokinetics of single and multiple ascending Oral doses of DA-8010 in healthy subjects: First-in-human phase I study. Pharmacol Res Perspect. 2023 Feb;11(1):e01040. doi: 10.1002/prp2.1040. PMID: 36734627; PMCID: PMC9897050.Lee DY, Lee MJ, Ryu C, Lee H, Brooks A.
